when looking at data clindamycin and cats obtained from studies with living mammalian cells, it appears reasonable clindamycin caduet medical and cats to assume that dequalinium molecules could be pulled into the mitochondrial matrix in response to the high mitochondrial membrane potential as demonstrated in , which in turn might lead to the destabilization of the dqasomepdna complex however, the first detailed study, which demonstrated the selective dna release from dqaplexes, was performed using membrane mimicking liposomes fig as a model for the intracellular release of dna from dqasomes, the capacity of anionic liposomes to displace the dna from its cationic carrier was studied the association of dna with the cationic carrier was clindamycin and cats assessed by employing sybr green i the fluorescence signal of clindamycin and cats this dye is greatly enhanced when bound to dna nonbinding results clindamycin and cats in loss of fluorescence it can be clearly seen that in the vicinity of a charge ratio, dqasomes do not clindamycin and cats release any dna in the presence of cytoplasmic membrane mimicking liposomes dqasomes s � � o � u a � � � cpm imm ��� anionic liposomes i � � clindamycin and cats time [sec] fig effect of anionic liposomes on dna release from dqasomepdna complexes dna was preincubated with sybr until stabilization of the signal, followed by clindamycin and cats adding indicated by arrow the minimal amount of dqasomes necessary to decrease the signal to background level anionic liposomes were then injected arrow at an anionic to cationic charge ratio as shown the displacement of dna from its carrier is clindamycin and cats indicated by the increase of clindamycin and cats the fluorescence signal cpm, cytoplasma membrane like liposomes imm, inner mitochondrial membrane like liposomes omm, outer clindamycin and cats mitochondrial membrane like liposomes cpm, not even at a fold excess of anionic charge however, with a similar charge excess clindamycin and cats of anionic liposomes to cationic dqasomes, and respectively, inner and outer mitochondrial membrane mimicking liposomes imm and omm, respectively are able to displace up to clindamycin and cats of the dna from its clindamycin and cats dqasomal carrier in agreement with these data, it was found that for the complete liberation of dna from dna dqasome complex, a fourfold excess of dicetylphosphate and an eightfold excess of phosphatidylserine, respectively, are necessary the finding that cpm liposomes, at an anionic to cationic charge ratio of , displace up to of the dna from lipofectin, which was used as a control, do not liberate any clindamycin and cats dna from dqasomes even at clindamycin and cats a slight excess of anionic charge, leads to the conclusion that besides the charge ratio, other factors may play an important role in the mechanism clindamycin and levitra tabs cats of dna release from lipiddna complexes this conclusion is being further supported by xu and clindamycin and cats szokas observation that ionic water soluble molecules such as atp, clindamycin and cats trna, dna, polyglutamic acid, spermidine and histone do not displace clindamycin and cats dna from the cationic lipiddna complex, even at a fold charge excess � in their clindamycin and cats model for the postendocytotic release of dna from cationic carriers, they assume the formation of clindamycin and cats a charge neutral ion pair between cationic and anionic lipid, which ultimately results in the clindamycin and cats displacement of the dna from the cationic lipid and the release of dna into cytoplasm liposomedna liposome ?