nanocapsules emulsion h nanoparticles t �� prednisolone eye drops after cataracr surgery microparticles fig indomethacin concentrations attained in the aqueous prednisolone eye drops after cataracr surgery humor following the topical application, in rabbits, of indomethacinloaded carriers and a control drug solution mean values � sd, n = , p compared with indocollyre p compared with colloidal suspensions reprinted from ref , with permission from pharmaceutical press immunosuppressive peptide cyclosporin a interestingly, following topical prednisolone eye drops after cataracr surgery administration of pecl nanocapsules containing cyclosporin a, we observed corneal levels of the drug which were five times higher than those provided by an oily solution topical formulation of cyclosporin typically used these high levels were not, however, translated into high drug concentrations in the prednisolone eye drops after cataracr surgery aqueous humor a result that was attributed to the important hydrophobicity of this peptide and prednisolone eye drops after cataracr surgery its tendency to associate with lypophylic components prednisolone eye drops after cataracr surgery therefore, at present, there is a proofofconcept of the efficacy of polyester nanocapsules for enhancing prednisolone eye drops after cataracr surgery the concentration of topically applied drugs in the corneal epithelium whether this enhanced concentration may or wellbutrin for weight loss may not lead to a favored accumulation prednisolone eye drops after cataracr surgery of the drug in the inner eye is expected to be largely dependent on the physicochemical characteristics of the drug polysaccharidebased nanoparticles prednisolone eye drops after cataracr surgery the polyester polymers described above are hydrophobic polymers prednisolone eye drops after cataracr surgery that need to be biodegraded into hydrophilic oligomers in order to be eliminated from the body a very different class of polymers, which has only received attention in the last few years, is the one represented by prednisolone eye drops after cataracr surgery the hydrophilic polysaccharides hyaluronic acid and chitosan are two types of polysaccharides which have opened prednisolone eye drops after cataracr surgery new prospects in the ocular drug delivery area the choice of hyaluronic acid has been justified by its bioadhesive character, but also by its well known safety profile in fact, prednisolone eye drops after cataracr surgery hyaluronic acid is already being used as a substitute for vitreous humor in intraocular surgery, prednisolone eye drops after cataracr surgery since it constitutes a basic component of the vitreous body on the other hand, chitosan is a polycationic biopolymer which exhibits several favorable prednisolone eye drops after cataracr surgery biological properties for ocular drug administration these prednisolone eye drops after cataracr surgery properties include mucoadhesiveness biodegradability in the rich lysozyme containing mucus ie ocular mucosa, and also prednisolone eye drops after cataracr surgery wound healing and antimicrobial activity despite the number of articles showing the efficacy of hyaluronic prednisolone eye drops after cataracr surgery acid solutions for improving the retention of drugs prednisolone eye drops after cataracr surgery applied topically onto the eye, the only particulate formulation that has been tested in vivo was composed of microparticles zm rather than nanoparticles these hyaluronate microparticles were shown to increase the residence time of the model drug methylprednisolone at the ocular surface of the rabbit eye taking into account the reported influence of the size on the interaction of particles with the ocular mucosa, we have recently designed nanoparticles consisting of hyaluronic acid and chitosan at present, we know that these nanoparticles are stable upon incubation in simulated lachrymal fluids and in vivo studies are in progress in prednisolone eye drops after cataracr surgery order to evaluate their mechanism of interaction with the ocular mucosa chitosan has also received significant attention in the ophthalmic field one of the chitosanbased systems that has exhibited an interesting behavior following topical ocular administration, is the one consisting of chitosan nanoparticles these nanoparticles have been tested on the rabbit model for their ability to enhance the concentration of prednisolone eye drops after cataracr surgery cyclosporin a at the level of the prednisolone eye drops after cataracr surgery ocular mucosa as expected, the results showed that the chitosan nanoparticles were able to increase the concentrations of cyclosporin a in the external ocular tissues cornea and conjunctiva significantly for prednisolone eye drops after cataracr surgery up to hr postinstillation fig despite this enhanced prednisolone eye drops after cataracr surgery retention of the drug in the external prednisolone eye drops after cataracr surgery tissues, the levels attained in the internal ocular structures ie aqueous humor, iris and ciliary body and in the blood were negligible consequently, these results suggested the utility of this new formulation for the treatment of surface eye diseases, ie dry eye or inflammatory diseases these high drug concentrations restricted to the periocular tissues were later explained by a high corneal and conjunctival surface retention of chitosan nanoparticles indeed, in a study consisting of evaluating the concentration of fluorescent chitosan, either in the form of nanoparticles or as a solution, in cornea and conjunctiva, we could conclude that the affinity of chitosan for the ocular prednisolone eye drops after cataracr surgery surface is greater when it is in a particulate form this conclusion invites interesting prospects with regard to the potential of chitosan nanoparticles as drug carriers for topical ocular administration keeping this in mind, we tested the acute tolerance of chitosan nanoparticles following topical instillation to rabbits very recently the results gave evidence of an excellent tolerance, without any sign prednisolone eye drops after cataracr surgery of irritation or damage of the ocular surface structures cya concentration in the cornea ng cyag cornea ?