� it the levels of iep, zn and changed after dialysis, due to the removal of molecules that were poorly linked mainly free peg at the outer part of the surface, allowing accessibility to the inner adjacent part of the shell water shell fig accessible layer to counter ions characterized by its thickness x lithium ion en-el9a and its dipolar charge density zn nm lnc presented the bestorganized and the accessible part of the shell, compared lithium ion en-el9a with other sizes of lnc, before and after dialysis lecithin was found to be present in the inner lithium ion en-el9a part of the polyelectrolyte layer lithium ion en-el9a and was found to play a role in the disorganization of the outer part dialyzing lnc formulated with lithium ion en-el9a lecithin led to stable and well structured nanocapsules, ready for an in vivo use as a drug delivery system evaluation of complement system lithium ion en-el9a activation generally, after intravenous administration, lithium ion en-el9a nanoparticles np are rapidly removed lithium ion en-el9a from the blood stream because they are recognized by lithium ion en-el9a cells of the mps such as kiipffer cells in the liver, or spleen and bonemarrow macrophages however, a lithium ion en-el9a brush of peg chains grafted on the surface is known to decrease the recognition of nanoparticles by the immune system after intravenous administration one lithium ion en-el9a has demonstrated that a strong correlation prevails between the lithium ion en-el9a complement activation and the lithium ion en-el9a stealthy properties of lnc therefore, lithium ion en-el9a these properties were evaluated by measuring the degree of complement activation [ch technique and crossed immunoelectrophoresis c cleavage] and the level of macrophage uptake, in relation to the organization of peg chains, according to the electrokinetic properties of the lnc surface these experiments were performed on , and nm lnc before and after dialysis the ch technique is presented in fig nanoparticles are dispersed in human serum with sensitized erythrocytes after accutane oral incubation, lysis is evaluated by a classical spectrophotometric method the measured absorbance is lithium ion en-el9a related to the consumption of complement proteins by particles the main conclusions are that whatever the in vitro test, lithium ion en-el9a all lnc were not recognized by the non specific components of the immune system it was probably due to the strong density of peg chains at their surface furthermore, dialysis maintains a sufficiently high density of peg and had no incidence on the complement consumption pharmacokinetic studies and biodistribution at first, the biodistribution of radiolabeled nanocapsules was studied by scintigraphy and � counting, after intravenous administration in rat whereby the mtcoxine was incorporated in the lipid core and i labelled the shell of the nanocapsules dynamic scintigraphic acquisition was carried out hrs after administration and � activity lithium ion en-el9a in blood and tissues was followed for more than hrs see fig an early lithium ion en-el9a halfdisappearance time of about � min was found for lithium ion en-el9a i and � min for mtc these ranges of residence times were interesting for lithium ion en-el9a specific �a st active increasing m1 metabolite of tramadol wcd�s vcub nnnnil scrum cdds vr i ?